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Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever. Try for free *Refers to first dose only.. With so many options, we often get asked what is the difference between products Studies show Zyrtec and Xyzal seem to be more effective than other Second antihistamines and last 24 hours. Xyzal (Levocetirizine), once a prescription only drug, was made available over the counter in the Spring of 2017. Xyzal is in a drug class called antihistamines. Until now, it has only been available with a prescription. Store at room temperature away from moisture and heat Take Xyzal at night! Xyzal Allergy 24HR, from Sanofi, contains levocetirizine, an antihistamine previously only available with a prescription May 30, 2017 Xyzal Available Over the Counter New OTC antihistamine is now available -Xyzal (levocetirizine). A Night and Day Difference in Allergy Relief Take Xyzal at Night. Over-the-counter medications are not typically covered by insurance plans. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). May 30, 2017 Xyzal Available Over the Counter New OTC antihistamine is now available -Xyzal (levocetirizine). With so many options, we often get asked what is the difference between products The active metabolite of hydroxyzine is cetirizine (Zyrtec), which is available over-the-counter as a low-sedating antihistamine. (antihistamine) Ages 12-64: take 1 tablet in the evening; Ages 6-11: take 1/2 a tablet in the evening; Ages 65 and older: ask a doctor; Ages 6 and under: do Re: Zyrtec vs Take Xyzal at night! Measure liquid medicine carefully. Additionally, on first dose, Xyzal provides faster relief than Claritin Both are available over-the-counter (OTC) without prescriptions. Try for free *Refers to first dose only Xyzal ( levocetirizine ) is an oral medication used to treat allergy symptoms or chronic hives. 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